Journal of the American Society for Mass Spectrometry

Explore highly cited articles published in the Journal of the American Society for Mass Spectrometry in the last few years, as well as highlights from 2020, covering the following topics:

Imaging MS

Fundamentals of gas phase ions

Ion mobility mass spectrometry

Ambient ionization of drugs of abuse

Single cell proteomics

Top down MS of proteins

Lipid characterization

Native MS

Glycan characterization

Polymers

Imaging MS

MSiReader v1.0: Evolving Open-Source Mass Spectrometry Imaging Software for Targeted and Untargeted Analyses

Mark T. Bokhart, Milad Nazari, Kenneth P. Garrard, and David C. Muddiman

DOI: 10.1021/jasms.8b05659

Towards High-Resolution Tissue Imaging Using Nanospray Desorption Electrospray Ionization Mass Spectrometry Coupled to Shear Force Microscopy

Son N. Nguyen, Ryan L. Sontag, James P. Carson, Richard A. Corley, Charles Ansong, and Julia Laskin

DOI: 10.1021/jasms.8b05739

Fundamentals of gas phase ions

IR-IR Conformation Specific Spectroscopy of Na⁺(Glucose) Adducts

Jonathan M. Voss, Steven J. Kregel, Kaitlyn C. Fischer, and Etienne Garand

DOI: 10.1021/jasms.8b05661

Modified Quadrupole Ion Trap Mass Spectrometer for Infrared Ion Spectroscopy: Application to Protonated Thiated Uridines

L. A. Hamlow, Y. Zhu, Zachary J. Devereaux, N. A. Cunningham, G. Berden, J. Oomens, and M. T. Rodgers

DOI: 10.1021/jasms.8b05714

Ion mobility mass spectrometry

Optimizing Native Ion Mobility Q-TOF in Helium and Nitrogen for Very Fragile Noncovalent Structures

Valérie Gabelica, Sandrine Livet, and Frédéric Rosu

DOI: 10.1021/jasms.8b05701

Comparison of Different Ion Mobility Setups Using Poly (Ethylene Oxide) PEO Polymers: Drift Tube, TIMS, and T-Wave

Jean R. N. Haler, Philippe Massonnet, Fabien Chirot, Christopher Kune, Clothilde Comby-Zerbino, Jan Jordens, Maarten Honing, Ynze Mengerink, Johann Far, Philippe Dugourd, and Edwin De Pauw

DOI: 10.1021/jasms.8b05667

Ambient ionization of drugs of abuse

Single cell proteomics

Paper Spray Tandem Mass Spectrometry Based on Molecularly Imprinted Polymer Substrate for Cocaine Analysis in Oral Fluid

Ludmyla S. Tavares, Thays C. Carvalho, Wanderson Romão, Boniek G. Vaz, and Andréa R. Chaves

DOI: 10.1021/jasms.8b05768

Enhanced Peptide Detection Toward Single-Neuron Proteomics by Reversed-Phase Fractionation Capillary Electrophoresis Mass Spectrometry

Sam B. Choi, Camille Lombard-Banek, Pablo Muñoz-LLancao, M. Chiara Manzini, and Peter Nemes

DOI: 10.1021/jasms.8b05800

Top down MS of proteins

Sequencing Larger Intact Proteins (30-70 kDa) with Activated Ion Electron Transfer Dissociation

Nicholas M. Riley, Michael S. Westphall, and Joshua J. Coon

DOI: 10.1021/jasms.8b05658

Top or Middle? Up or Down? Toward a Standard Lexicon for Protein Top-Down and Allied Mass Spectrometry Approaches

Frederik Lermyte, Yury O. Tsybin, Peter B. O’Connor, and Joseph A. Loo

DOI: 10.1021/jasms.8b06046

Lipid characterization

Charging and Charge Switching of Unsaturated Lipids and Apolar Compounds Using Paternò-Büchi Reactions

Patrick Esch and Sven Heiles

DOI: 10.1021/jasms.8b05694

Mapping Unsaturation in Human Plasma Lipids by Data-Independent Ozone-Induced Dissociation

David L. Marshall, Angela Criscuolo, Reuben S. E. Young, Berwyck L. J. Poad, Martin Zeller, Gavin E. Reid, Todd W. Mitchell, and Stephen J. Blanksby

DOI: 10.1021/jasms.8b06095

Native MS

MetaUniDec: High-Throughput Deconvolution of Native Mass Spectra

Deseree J. Reid, Jessica M. Diesing, Matthew A. Miller, Scott M. Perry, Jessica A. Wales, William R. Montfort, and Michael T. Marty

DOI: 10.1021/jasms.8b05914

Fourier Transform-Ion Cyclotron Resonance Mass Spectrometry as a Platform for Characterizing Multimeric Membrane Protein Complexes

Jennifer L. Lippens, Michael Nshanian, Chris Spahr, Pascal F. Egea, Joseph A. Loo, and Iain D. G. Campuzano

DOI: 10.1021/jasms.8b05657

Glycan characterization

Discrimination of Isomers of Released N - and O -Glycans Using Diagnostic Product Ions in Negative Ion PGC-LC-ESI-MS/MS

Christopher Ashwood, Chi-Hung Lin, Morten Thaysen-Andersen, and Nicolle H. Packer

DOI: 10.1021/jasms.8b05838

Cyclic Ion Mobility Mass Spectrometry Distinguishes Anomers and Open-Ring Forms of Pentasaccharides

Jakub Ujma, David Ropartz, Kevin Giles, Keith Richardson, David Langridge, Jason Wildgoose, Martin Green, and Steven Pringle

DOI: 10.1021/jasms.8b06021

Polymers

On the Kendrick Mass Defect Plots of Multiply Charged Polymer Ions: Splits, Misalignments, and How to Correct Them

Thierry N. J. Fouquet, Robert B. Cody, Yuka Ozeki, Shinya Kitagawa, Hajime Ohtani, and Hiroaki Sato

DOI: 10.1021/jasms.8b05877

2020 highlights include:

Fundamentals of gas phase ions

Role of Chemical Dynamics Simulations in Mass Spectrometry Studies of Collision-Induced Dissociation and Collisions of Biological Ions with Organic Surfaces

Ana Martin Somer, Veronica Macaluso, George L. Barnes, Li Yang, Subha Pratihar, Kihyung Song, William L. Hase, and Riccardo Spezia

DOI: 10.1021/jasms.9b00062

Protein crosslinking MS

To Cleave or Not To Cleave in XL-MS?

B. Steigenberger, P. Albanese, A. J. R. Heck, and R. A. Scheltema

DOI: 10.1021/jasms.9b00085

Ambient ionization of drugs of abuse

Identification and Confirmation of Fentanyls on Paper using Portable Surface Enhanced Raman Spectroscopy and Paper Spray Ionization Mass Spectrometry

Patrick W. Fedick, Fan Pu, Nicolás M. Morato, and R. Graham Cooks

DOI: 10.1021/jasms.0c00004